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  Effects of endocrine treatment: can libido and sexual function be preserved?

  Introduction Quality of life for men with prostate cancer is receiving increasing attention and, acknowledging that endocrine therapy remains conceptually a palliative treatment, many patients view preservation of quality of life as an equally important goal of therapy as prolongation of survival. The issue of quality of life is further emphasized by the moves to initiate endocrine therapy earlier in the course of the disease and in younger men. Sexuality is an important aspect of quality of life, particularly in middle-aged men but also for a majority of elderly men. However, loss of libido and erectile dysfunction are frequent sequelae of the diagnosis and treatment of prostate cancer. Among 401 men with prostate cancer, 71% experienced a loss of libido...

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  Canadian Health&Care Medstore: 5 Steps To Take Before Ordering Pills

  Canadian Health&Care Medstore: 5 Steps To Take Before Ordering Pills When you experience one failure in bed after another, it is logical to jump to a fast conclusion that you are developing ED. On the other hand, it may signal something else. A visit to the doctor's office will let you know if impotence is your case. Canadian Pharmacy recommends taking a few steps with the first alarming signs. Step 1 See a doctor. The doctor will take your medical and sexual history. By asking questions about your erections the doctor will establish frequency and duration of the problem. The look into your sexual history will also help the doctor find the relationship problems that can cause a low sexual...

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  Canadian Pharmacy Test: Caffeine

  Canadian Pharmacy Test: Caffeine In 2011, an influential paper focused scientific and media attention on a possible negative effect of caffeine on fertility. In a prospective study, Wilcox and colleagues looked at the chance of having a clinically detectable pregnancy, related to the level of caffeine consumed in beverages. One cup of 'real' coffee was estimated to contain 100 mg of caffeine, instant coffee 65 mg, tea 50 mg and cola soft drinks 40 mg. Women who consumed more than 100 mg/day caffeine were classified as having a high caffeine intake. Compared with women drinking less than 100 mg/day, high-caffeine consumers had a 50% reduction in their chance of conception in any particular month. In the low-caffeine group, 6% had...

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  Carbonic anhydrase inhibitors

  Carbonic anhydrase inhibitors Carbonic anhydrase inhibitors (CAI) are used for the management of glaucoma, although some are also indicated for the management of water retention and familial cerebellar ataxia. The main reporting of side effects is from ophthalmological practice. The National Registry of Drug Induced Ocular Side Effects in the USA reported 39 cases of decreased libido in patients on CAI. The preparations used included acetazolamide, dichlorphenamide and methazolamide. In 24 of the cases, the patients had actually demanded of their doctors whether the drug was having an effect on their sexual function. Most patients were taking other drugs concomitantly. In all cases, the symptoms resolved on stopping the CAI. Twelve patients restarted the drug and this was followed by...

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  Cardiovascular drugs – Antiarrhythmics

  Cardiovascular drugs - Antiarrhythmics Disopyramide Disopyramide is used for the prevention and control of a wide variety of cardiac arrhythmias. At least two case reports have described the development of impotence but with no loss of sexual desire in patients on disopyramide. One patient developed impotence on a dose of 300^400 mg disopyramide. At this time plasma disopyramide concentration was14|ug/ml. The dosage was reduced and full recovery of sexual function occurred when the plasma concentration fell to 3 jug/ml. In another case, impotence developed in a 35-year-old man within 3 weeks of commencing disopyramide. Six days after withdrawal of the drug, sexual potency returned. Disopyramide was later recommenced because of a recurrence of his ectopic beats and the sexual dysfunction...

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  Nitrofurans: Niridazole and other antibiotics

  Nitrofurans Niridazole Niridazole is a nitrothiazole derivative related to metronidazole and is widely used in some countries for the treatment of schistosomiasis. In rodent species, it has been found to affect spermatogenesis during meiosis. A study of 25 men with bilharzia in Egypt showed that a 10 day course of treatment depressed semen volume and sperm count and motility 1 week after cessation of treatment. This persisted 3 months after treatment was discontinued. Testicular biopsy at 1 week in eight men showed focal germinal cell hypoplasia and/or spermatocyte arrest. At 3 months, repeat testicular biopsy in these men showed normal spermatogenesis in six but persistant abnormalities in the remaining two subjects. Nitrofurantoin Early studies in rats showed that nitrofurans including...

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  Antibiotics: Sulphonamides

  Antibiotics: Sulphonamides Sulphasalazine Sulphasalazine has been used in the treatment of inflammatory bowel disease since 1942, although the first reports of sperm toxicity only appeared in 1979. Sulphasalazine is taken orally and reaches the colon intact. As a result of the action of colonic bacteria, the compound is split into its constituents sulphapyridine and 5-aminosalicylic acid. It is useful to follow the sulphasalazine story in some detail. It is one of the few drugs for which clinical observation of reproductive side effects has led to detailed study of the underlying mechanisms responsible for the side effects. This has resulted in identification of the toxic component and a change in the pharmacological formulation. Two separate reports in 1979 drew attention to...

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  Miscellaneous hormones

  Miscellaneous hormones Bromocriptine Bromocriptine is a dopamine agonist widely used in the treatment of hyperprolactinaemia. This disorder is characterised by amenorrhoea and galactorrhoea in women and impotence in males. Infertility is a common presentation of hyperprolactinaemia. Therapy with bromocriptine is generally highly effective in suppressing the elevated prolactin levels and this is associated with a return to normal menstruation in females (secondary to restoration of ovulation) and return to normal sexual function in men. Bromocriptine has also been used to restore normal sexual function to uraemic men undergoing haemodialysis, who are frequently affected by reduced libido and potency disorders. In Parkinson's disease, however, the use of bromocriptine has been reported to induce impotence. Cleeves and Findley described four patients who...

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  Hormone Therapy – Progestogens

  Progestogens Until recently, natural progesterone could not be administered orally as it was broken down in the gastrointestinal tract. Micronised progesterone preparations are now available in some countries but synthetic progestogens are the most widely used. They are divided into two groups. The testosterone analogues include norethisterone, norgestrel and the norgestrel derivatives, i.e. desogestrel, norgestimate and gestodene. Progesterone derivatives are allyloestrenol, dydrogesterone, hydroxyprogesterone and medroxyprogesterone. Progestational agents have many uses in gynaecology. They are prescribed for contraception, menorrhagia, dysmenorrhoea, premenstrual syndrome, endometriosis, threatened miscarriage and adjuvant therapy for endometrial carcinoma. Progestogens are also added to oestrogens in hormone-replacement therapy in women being treated for perimenopausal symptoms. The effects on reproductive function depend on several factors including the molecular structure, i.e....

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  Canadian Viagra in AcanadianHealthCareMall.Com

  Viagra is a drug with the active ingredient sildenafil which is universally known as being effective in treating of erectile dysfunction. Erectile dysfunction, or ED, is a condition characterized by the inability of people to get a normal erection, which would allow him to have sex without worrying about the hardness of the erection. Therefore, it is important to buy Viagra online from a trusted source, if you are sure that you have purchased Viagra and Viagra will help you treat your condition. Before you decide to buy Viagra Canada online, you must remember that you will need to have your health condition assessed by your practitioner in order to rule out potential contraindications and incompatibilities with other medicines you...

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