Antibiotics: Sulphonamides Sulphasalazine Sulphasalazine has been used in the treatment of inflammatory bowel disease since 1942, although the first reports of sperm toxicity only appeared in 1979. Sulphasalazine is taken orally and reaches the colon intact. As a result of the action of colonic bacteria, the compound is split into its constituents sulphapyridine and 5-aminosalicylic […]
Progestogens Until recently, natural progesterone could not be administered orally as it was broken down in the gastrointestinal tract. Micronised progesterone preparations are now available in some countries but synthetic progestogens are the most widely used. They are divided into two groups. The testosterone analogues include norethisterone, norgestrel and the norgestrel derivatives, i.e. desogestrel, norgestimate […]
Viagra is a drug with the active ingredient sildenafil which is universally known as being effective in treating of erectile dysfunction. Erectile dysfunction, or ED, is a condition characterized by the inability of people to get a normal erection, which would allow him to have sex without worrying about the hardness of the erection. Therefore, […]
The aPTT should be measured approximately 6 h after the bolus dose of heparin, and the continuous IV dose should be adjusted according to the result. Various heparin dose-adjustment nomograms have been developed (Tables 4 and 5), but none are applicable to all aPTT reagents, and, for the reasons discussed above, the therapeutic range should be adapted to the responsiveness of […]
The American College of Cardiology recommends a heparin bolus of 60 to 70 U/kg (maximum dose, 5,000 U) and the infusion of 12 to 15 U/kg/h (maximum dose, 1,000 U per hour) for unstable angina and non-ST-segment elevation myocardial infarction (MI), and somewhat lower dosing (60 U/kg bolus [maximum dose, 4,000 U], and 12 U/kg infusion (maximum dose, 1,000 U per […]
AMP Challenge Airway responsiveness to AMP was assessed using a standardized dosimetric method, as described in detail previously. AMP (Sigma Chemical; St. Louis, MO) was dissolved freshly in 0.9% saline solution to produce a doubling concentration range of 0.39 to 400 mg/mL. Each solution was administered from a jet nebulizer attached to a breath-activated dosimeter (model MB3; Mefar; Brescia, […]
DIET AND INSULIN I have been told that I am going to have to start insulin after many years of diet and tablets. Will my diet need to change? It would be helpful if you could discuss your present eating habits and lifestyle with a dietitian before you start on insulin. If you have been […]
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